MolNFT v1 · #541948 · protein
AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (P39447)
P39447: “AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (P39447)”. 11 pockets (best druggability 0.71). MolNFT v1 #541948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P39447
- Type
- protein
- Length
- 1,745 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7782F4817b37743d738e9aF842bf74bd50f2015E
- Molecule
- Tight junction protein zo-1
- UniProt
- P39447
- Pockets
- 11 · best druggability 0.71
Structure
1 distinct chain · 11% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tight junction protein zo-1 | protein | 1745 | 11% helix, 13% strand | P39447 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 693 | 0.71 | 0.78 | 57 | empty |
| 2 | 403 | 0.70 | 0.82 | 36 | empty |
| 3 | 413 | 0.59 | 0.75 | 43 | empty |
| 4 | 116 | 0.56 | 0.84 | 12 | empty |
| 5 | 161 | 0.50 | 0.78 | 22 | empty |
Compared structures
- 2RRM · Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st… · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2RRM · Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1ST… · an experimental structure of the same protein · chain A against A, TM-score 0.05
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39447
- Elsewhere: UniProt P39447 · AlphaFold DB P39447
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