MolNFT v1 · #499963 · protein
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK4 (Q96J92)
Q96J92: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK4 (Q96J92)”. 6 pockets (best druggability 0.67). MolNFT v1 #499963 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q96J92
- Type
- protein
- Length
- 1,243 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7FDF8b382C6a36A8772D1A265E8e480c7DF0A9C1
- Molecule
- SERINE/THREONINE-protein kinase WNK4
- UniProt
- Q96J92
- Pockets
- 6 · best druggability 0.67
Structure
1 distinct chain · 19% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase WNK4 | protein | 1243 | 19% helix, 9% strand | Q96J92 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 287 | 0.67 | 0.82 | 38 | empty |
| 2 | 174 | 0.47 | 0.76 | 23 | empty |
| 3 | 166 | 0.46 | 0.76 | 23 | empty |
| 4 | 83 | 0.37 | 0.77 | 14 | empty |
| 5 | 62 | 0.36 | 0.78 | 15 | empty |
Compared structures
- 4CH9 · Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4CH9 · Crystal structure of the human KLHL3 kelch domain in complex with a WNK4 peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4CHB · Crystal structure of the human KLHL2 kelch domain in complex with a WNK4 peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 4CHB · Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide · an experimental structure of the same protein · chain A against C, TM-score 0.01
- 2V3S · Structural insights into the recognition of substrates and activators by the OSR1 kinase · an experimental structure of the same protein · chain A against C, TM-score 0.00
- 2V3S · Structural insights into the recognition of substrates and activators by the OSR1 kinase · an experimental structure of the same protein · chain A against C, TM-score 0.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96J92
- Elsewhere: UniProt Q96J92 · AlphaFold DB Q96J92
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