MolNFT v1 · #499948 · protein
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9H4A3)
Q9H4A3: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9H4A3)”. 7 pockets (best druggability 0.75). MolNFT v1 #499948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9H4A3
- Type
- protein
- Length
- 2,382 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB44F19a0cb161828322eEEd13F55d4C3C34938d2
- Molecule
- SERINE/THREONINE-protein kinase WNK1
- UniProt
- Q9H4A3
- Pockets
- 7 · best druggability 0.75
Structure
1 distinct chain · 11% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase WNK1 | protein | 2382 | 11% helix, 5% strand | Q9H4A3 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.75 | 0.80 | 66 | empty |
| 2 | 91 | 0.65 | 0.91 | 22 | empty |
| 3 | 104 | 0.41 | 0.77 | 17 | empty |
| 4 | 120 | 0.38 | 0.74 | 16 | empty |
| 5 | 122 | 0.38 | 0.74 | 24 | empty |
Compared structures
- 5WE8 · Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-y… · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 5WE8 · Crystal structure of WNK1 in complex with N-{(3R)-1-[(4-chlorophenyl)… · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 5TF9 · Crystal structure of WNK1 in complex with MN2+AMPPNP and WNK476 · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 5TF9 · Crystal structure of WNK1 in complex with Mn2+AMPPNP and WNK476 · an experimental structure of the same protein · chain A against B, TM-score 0.11
- 5WDY · Crystal structure of WNK1 in complex with 1-cyclohexyl-N-({6-fluoro-1… · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 5WDY · Crystal structure of WNK1 in complex with 1-cyclohexyl-N-({6-fluoro-1-[2-(3-methoxyphenyl)… · an experimental structure of the same protein · chain A against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H4A3
- Elsewhere: UniProt Q9H4A3 · AlphaFold DB Q9H4A3
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