AlphaFold monomer V2.0 prediction for von hippel-lindau disease tumor suppressor (P40337)

Structure

1 distinct chain · 21% helix, 20% strand (DSSP).

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 7PI4 · FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB · an experimental structure of the same protein · chain A against AAA, TM-score 0.72
• 8BB3 · Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker… · an experimental structure of the same protein · chain A against L, TM-score 0.71
• 8BB5 · Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with Aryl linker · an experimental structure of the same protein · chain A against C, TM-score 0.71
• 6R7F · Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome · an experimental structure of the same protein · chain A against V, TM-score 0.71
• 8WDK · The complex structure of Cul2-VCB-Protac-Wee1 · an experimental structure of the same protein · chain A against V, TM-score 0.71
• 6ZHC · PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL · an experimental structure of the same protein · chain A against AAA, TM-score 0.71
• 8QJR · BRG1 bromodomain in complex with VBC via compound 17 · an experimental structure of the same protein · chain A against F, TM-score 0.70
• 6BVB · Crystal structure of HIF-2alpha-pVHL-elongin B-elongin C · an experimental structure of the same protein · chain A against V, TM-score 0.70
• 8EI3 · Crystal structure of VHL in complex with H313, a Helicon Polypeptide · an experimental structure of the same protein · chain A against F, TM-score 0.70
• 6HAY · Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and… · an experimental structure of the same protein · chain A against B, TM-score 0.70
• 7Z77 · Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and… · an experimental structure of the same protein · chain A against C, TM-score 0.70
• 6I7Q · Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha… · an experimental structure of the same protein · chain A against V, TM-score 0.70

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P40337
• Elsewhere: UniProt P40337 · AlphaFold DB P40337