MolNFT v1 · #488491 · protein

AlphaFold monomer V2.0 prediction for ubiquitin-like-specific protease 2 (P40537)

P40537: “AlphaFold monomer V2.0 prediction for ubiquitin-like-specific protease 2 (P40537)”. 10 pockets (best druggability 0.71). MolNFT v1 #488491 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P40537
Type: protein
Length: 1,034 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xF3b04d65F1aD0058771B149FB8BD62b3934a8918
Molecule: Ubiquitin-like-specific protease 2
UniProt: P40537
Pockets: 10 · best druggability 0.71

Structure

1 distinct chain · 21% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-like-specific protease 2	protein	1034	21% helix, 11% strand	P40537

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	743	0.71	0.77	69	empty
2	358	0.65	0.80	39	empty
3	342	0.59	0.76	30	empty
4	185	0.55	0.79	23	empty
5	171	0.50	0.77	25	empty

Compared structures

5LNB · Crystal structure of the de-sumoylating protease · an experimental structure of the same protein · chain A against B, TM-score 0.25
5LNB · Crystal structure of the de-sumoylating protease · an experimental structure of the same protein · chain A against B, TM-score 0.25
5V1A · Structure of S. cerevisiae ULP2:CSM1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.02
5V1A · Structure of S. cerevisiae Ulp2:Csm1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.02

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40537
Elsewhere: UniProt P40537 · AlphaFold DB P40537

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