MolNFT v1 · #478171 · protein
AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M member 8 (Q7Z2W7)
Q7Z2W7: “AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M member 8…”. 13 pockets (best druggability 0.77). MolNFT v1 #478171 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q7Z2W7
- Type
- protein
- Length
- 1,104 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3298b100681D3A2372Bba3b2f282750dD71629B9
- Molecule
- Transient receptor potential cation channel subfamily M member 8
- UniProt
- Q7Z2W7
- Pockets
- 13 · best druggability 0.77
Structure
1 distinct chain · 60% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily M member 8 | protein | 1104 | 60% helix, 8% strand | Q7Z2W7 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.77 | 0.93 | 27 | empty |
| 2 | 387 | 0.69 | 0.81 | 60 | empty |
| 3 | 460 | 0.62 | 0.76 | 50 | empty |
| 4 | 242 | 0.58 | 0.79 | 29 | empty |
| 5 | 249 | 0.53 | 0.76 | 38 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8BDC · Human apo TRPM8 in a closed state (composite map) · an experimental structure of the same protein · chain A against B, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z2W7
- Elsewhere: UniProt Q7Z2W7 · AlphaFold DB Q7Z2W7
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