MolNFT v1 · #473503 · protein
AlphaFold monomer V2.0 prediction for tRNA (GUANINE(26)-N(2)/GUANINE(27)-N(2))-dimethyltransferase (O67010)
O67010: “AlphaFold monomer V2.0 prediction for tRNA (GUANINE(26)-N(2)/GUANINE(27)-N(2))-dimethyltransferase (O67010)”. 5 pockets (best druggability 0.55). MolNFT v1 #473503 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O67010
- Type
- protein
- Length
- 392 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xd1A2963012bEcbC7A8f505464439Ab678C48936f
- Molecule
- TRNA (GUANINE(26)-N(2)/GUANINE(27)-N(2))-dimethyltransferase
- UniProt
- O67010
- Pockets
- 5 · best druggability 0.55
Structure
1 distinct chain · 43% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (GUANINE(26)-N(2)/GUANINE(27)-N(2))-dimethyltransferase | protein | 392 | 43% helix, 23% strand | O67010 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.55 | 0.81 | 30 | empty |
| 2 | 91 | 0.40 | 0.77 | 17 | empty |
| 3 | 71 | 0.31 | 0.74 | 15 | empty |
| 4 | 62 | 0.29 | 0.74 | 18 | empty |
| 5 | 64 | 0.29 | 0.74 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3AXS · Complex structure of tRNA methyltransferase Trm1 from Aquifex aeolicus with sinefungin · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 3AXS · Complex structure of tRNA methyltransferase TRM1 from aquifex aeolicus with sinefungin · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 3AXT · Complex structure of tRNA methyltransferase Trm1 from Aquifex aeolicus with… · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 3AXT · Complex structure of tRNA methyltransferase TRM1 from aquifex aeolicus with… · an experimental structure of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67010
- Elsewhere: UniProt O67010 · AlphaFold DB O67010
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