MolNFT v1 · #472666 · protein

AlphaFold monomer V2.0 prediction for transferrin (P22297)

P22297: “AlphaFold monomer V2.0 prediction for transferrin (P22297)”. 10 pockets (best druggability 0.63). MolNFT v1 #472666 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P22297
Type: protein
Length: 681 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xF976194c67263Fe25C9A4fcAb3b5c3409a4Ed3E7
Molecule: Transferrin
UniProt: P22297
Pockets: 10 · best druggability 0.63

Structure

1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transferrin	protein	681	36% helix, 19% strand	P22297

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.63	0.90	24	empty
2	518	0.63	0.76	48	empty
3	155	0.46	0.76	21	empty
4	104	0.44	0.79	16	empty
5	156	0.44	0.75	20	empty

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

6WB6 · 2.05 a resolution structure of transferrin 1 from manduca sexta · an experimental structure of the same protein · chain A against B, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22297
Elsewhere: UniProt P22297 · AlphaFold DB P22297

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