MolNFT v1 · #472420 · protein

AlphaFold monomer V2.0 prediction for tRNA (CYTOSINE(38)-C(5))-methyltransferase (O14717)

O14717: “AlphaFold monomer V2.0 prediction for tRNA (CYTOSINE(38)-C(5))-methyltransferase (O14717)”. 4 pockets (best druggability 0.63). MolNFT v1 #472420 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: O14717
Type: protein
Length: 391 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x7F23C94bd28B14B8fd19Fd1aC6EC1f9697562953
Molecule: TRNA (CYTOSINE(38)-C(5))-methyltransferase
UniProt: O14717
Pockets: 4 · best druggability 0.63

Structure

1 distinct chain · 34% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TRNA (CYTOSINE(38)-C(5))-methyltransferase	protein	391	34% helix, 13% strand	O14717

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	344	0.63	0.79	43	empty
2	132	0.50	0.79	18	empty
3	56	0.30	0.76	14	empty
4	67	0.30	0.74	17	empty

Compared structures

1G55 · Structure of human DNMT2, an enigmatic DNA methyltransferase homologue · an experimental structure of the same protein · chain A against A, TM-score 0.80
1G55 · Structure of human DNMT2, an enigmatic DNA methyltransferase homologue · an experimental structure of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14717
Elsewhere: UniProt O14717 · AlphaFold DB O14717

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