MolNFT v1 · #471893 · protein
AlphaFold monomer V2.0 prediction for protein-tyrosine sulfotransferase 2 (O60704)
O60704: “AlphaFold monomer V2.0 prediction for protein-tyrosine sulfotransferase 2 (O60704)”. 4 pockets (best druggability 0.70). MolNFT v1 #471893 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O60704
- Type
- protein
- Length
- 377 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7a1388B6Aad67B04634A32f63b8A6D6005eab86c
- Molecule
- Protein-tyrosine sulfotransferase 2
- UniProt
- O60704
- Pockets
- 4 · best druggability 0.70
Structure
1 distinct chain · 52% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine sulfotransferase 2 | protein | 377 | 52% helix, 8% strand | O60704 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.70 | 0.90 | 23 | empty |
| 2 | 258 | 0.57 | 0.78 | 31 | empty |
| 3 | 88 | 0.42 | 0.78 | 19 | empty |
| 4 | 100 | 0.35 | 0.74 | 19 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3AP2 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3AP2 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3AP1 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP and C4… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3AP1 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with pap and C4… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3AP3 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with pap · an experimental structure of the same protein · chain A against D, TM-score 0.77
- 3AP3 · Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP · an experimental structure of the same protein · chain A against D, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60704
- Elsewhere: UniProt O60704 · AlphaFold DB O60704
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