MolNFT v1 · #470036 · protein
AlphaFold monomer V2.0 prediction for DNA topoisomerase 2 (P30190)
P30190: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 2 (P30190)”. 15 pockets (best druggability 0.79). MolNFT v1 #470036 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P30190
- Type
- protein
- Length
- 1,232 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x362a6d063b1B7E1B6EfD3A9A7CA3612e3FE037AA
- Molecule
- DNA topoisomerase 2
- UniProt
- P30190
- Pockets
- 15 · best druggability 0.79
Structure
1 distinct chain · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2 | protein | 1232 | 41% helix, 19% strand | P30190 |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 923 | 0.79 | 0.81 | 66 | empty |
| 2 | 320 | 0.73 | 0.86 | 37 | empty |
| 3 | 571 | 0.67 | 0.77 | 66 | empty |
| 4 | 93 | 0.52 | 0.83 | 16 | empty |
| 5 | 113 | 0.50 | 0.80 | 25 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30190
- Elsewhere: UniProt P30190 · AlphaFold DB P30190
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