MolNFT v1 · #470027 · protein

AlphaFold monomer V2.0 prediction for DNA topoisomerase 2 (P27570)

P27570: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 2 (P27570)”. 15 pockets (best druggability 0.81). MolNFT v1 #470027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P27570
Type: protein
Length: 1,239 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5fa8aF910eDA471127Dc4EC5b737223f437dc3e0
Molecule: DNA topoisomerase 2
UniProt: P27570
Pockets: 15 · best druggability 0.81

Structure

1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA topoisomerase 2	protein	1239	40% helix, 18% strand	P27570

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	954	0.81	0.82	93	empty
2	277	0.71	0.85	38	empty
3	241	0.64	0.83	37	empty
4	208	0.63	0.83	36	empty
5	301	0.59	0.78	39	empty

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27570
Elsewhere: UniProt P27570 · AlphaFold DB P27570

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