MolNFT v1 · #470012 · protein
AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P41516)
P41516: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P41516)”. 13 pockets (best druggability 0.80). MolNFT v1 #470012 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P41516
- Type
- protein
- Length
- 1,526 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf4ED13986579E8e227b3ED6c02276c648754EC27
- Molecule
- DNA topoisomerase 2-alpha
- UniProt
- P41516
- Pockets
- 13 · best druggability 0.80
Structure
1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2-alpha | protein | 1526 | 34% helix, 15% strand | P41516 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 911 | 0.80 | 0.82 | 75 | empty |
| 2 | 279 | 0.74 | 0.87 | 40 | empty |
| 3 | 238 | 0.66 | 0.84 | 33 | empty |
| 4 | 261 | 0.66 | 0.83 | 39 | empty |
| 5 | 330 | 0.62 | 0.78 | 42 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41516
- Elsewhere: UniProt P41516 · AlphaFold DB P41516
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