MolNFT v1 · #470011 · protein
AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (O46374)
O46374: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (O46374)”. 12 pockets (best druggability 0.80). MolNFT v1 #470011 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O46374
- Type
- protein
- Length
- 1,533 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xCD02372865c553eFF897aF289Ecf524a0ff9D69e
- Molecule
- DNA topoisomerase 2-alpha
- UniProt
- O46374
- Pockets
- 12 · best druggability 0.80
Structure
1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2-alpha | protein | 1533 | 34% helix, 15% strand | O46374 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 702 | 0.80 | 0.85 | 69 | empty |
| 2 | 257 | 0.73 | 0.87 | 37 | empty |
| 3 | 220 | 0.68 | 0.86 | 35 | empty |
| 4 | 247 | 0.66 | 0.83 | 33 | empty |
| 5 | 324 | 0.60 | 0.78 | 45 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O46374
- Elsewhere: UniProt O46374 · AlphaFold DB O46374
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