MolNFT v1 · #470007 · protein
AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P41515)
P41515: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-alpha (P41515)”. 16 pockets (best druggability 0.82). MolNFT v1 #470007 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P41515
- Type
- protein
- Length
- 1,526 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xaa53776A41fB2e67da75A96E8a53746b6874aAB4
- Molecule
- DNA topoisomerase 2-alpha
- UniProt
- P41515
- Pockets
- 16 · best druggability 0.82
Structure
1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2-alpha | protein | 1526 | 34% helix, 15% strand | P41515 |
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1178 | 0.82 | 0.83 | 103 | empty |
| 2 | 253 | 0.74 | 0.88 | 33 | empty |
| 3 | 269 | 0.66 | 0.82 | 33 | empty |
| 4 | 391 | 0.62 | 0.77 | 47 | empty |
| 5 | 496 | 0.61 | 0.75 | 54 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41515
- Elsewhere: UniProt P41515 · AlphaFold DB P41515
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