MolNFT v1 · #469954 · protein
AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (O27661)
O27661: “AlphaFold monomer V2.0 prediction for DNA topoisomerase 1 (O27661)”. 5 pockets (best druggability 0.72). MolNFT v1 #469954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O27661
- Type
- protein
- Length
- 718 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x80DFF74473FD79110bd730F367842ad5E57E8738
- Molecule
- DNA topoisomerase 1
- UniProt
- O27661
- Pockets
- 5 · best druggability 0.72
Structure
1 distinct chain · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 1 | protein | 718 | 38% helix, 24% strand | O27661 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 840 | 0.72 | 0.77 | 80 | empty |
| 2 | 217 | 0.53 | 0.77 | 33 | empty |
| 3 | 105 | 0.45 | 0.78 | 16 | empty |
| 4 | 168 | 0.45 | 0.75 | 24 | empty |
| 5 | 69 | 0.32 | 0.74 | 19 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O27661
- Elsewhere: UniProt O27661 · AlphaFold DB O27661
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.