MolNFT v1 · #462650 · protein

AlphaFold monomer V2.0 prediction for tetrahydrocannabinolic acid synthase (Q8GTB6)

Q8GTB6: “AlphaFold monomer V2.0 prediction for tetrahydrocannabinolic acid synthase (Q8GTB6)”. 3 pockets (best druggability 0.83). MolNFT v1 #462650 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q8GTB6
Type: protein
Length: 545 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5BeA89782341f98147F2D811B063F91F0aE7D7bF
Molecule: Tetrahydrocannabinolic acid synthase
UniProt: Q8GTB6
Pockets: 3 · best druggability 0.83

Structure

1 distinct chain · 34% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetrahydrocannabinolic acid synthase	protein	545	34% helix, 21% strand	Q8GTB6

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	967	0.83	0.84	87	empty
2	125	0.40	0.75	26	empty
3	60	0.32	0.76	15	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3VTE · Crystal structure of tetrahydrocannabinolic acid synthase from Cannabis sativa · an experimental structure of the same protein · chain A against A, TM-score 0.92
3VTE · Crystal structure of tetrahydrocannabinolic acid synthase from cannabis sativa · an experimental structure of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8GTB6
Elsewhere: UniProt Q8GTB6 · AlphaFold DB Q8GTB6

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