MolNFT v1 · #462615 · protein
AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P04625)
P04625: “AlphaFold monomer V2.0 prediction for thyroid hormone receptor alpha (P04625)”. 3 pockets (best druggability 0.83). MolNFT v1 #462615 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P04625
- Type
- protein
- Length
- 408 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x93B835B47972632E65dc11270e23B6d8C9ef14a3
- Molecule
- Thyroid hormone receptor alpha
- UniProt
- P04625
- Pockets
- 3 · best druggability 0.83
Structure
1 distinct chain · 55% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroid hormone receptor alpha | protein | 408 | 55% helix, 5% strand | P04625 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.83 | 0.98 | 33 | empty |
| 2 | 161 | 0.47 | 0.77 | 19 | empty |
| 3 | 102 | 0.43 | 0.78 | 20 | empty |
Compared structures
- 3UVV · Crystal structure of the ligand binding domains of the thyroid RECEPTOR:RETINOID X… · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 3UVV · Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X… · an experimental structure of the same protein · chain A against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04625
- Elsewhere: UniProt P04625 · AlphaFold DB P04625
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