AlphaFold monomer V2.0 prediction for general transcription factor iih subunit 1 (P32780)

Structure

1 distinct chain · 52% helix, 9% strand (DSSP).

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 8BYQ · RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) · an experimental structure of the same protein · chain A against 2, TM-score 0.62
• 6O9M · Structure of the human apo TFIIH · an experimental structure of the same protein · chain A against 1, TM-score 0.61
• 6O9M · Structure of the human apo tfiih · an experimental structure of the same protein · chain A against 1, TM-score 0.61
• 7ENA · TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) · an experimental structure of the same protein · chain A against 1, TM-score 0.61
• 7EGC · p53-bound TFIID-based holo PIC on HDM2 promoter · an experimental structure of the same protein · chain A against 1, TM-score 0.59
• 8EBS · Initial DNA-lesion (Cy5) binding by XPC and TFIIH · an experimental structure of the same protein · chain A against C, TM-score 0.59
• 7ENC · TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) · an experimental structure of the same protein · chain A against 1, TM-score 0.59
• 6O9L · Human holo-pic in the closed state · an experimental structure of the same protein · chain A against 1, TM-score 0.57
• 6O9L · Human holo-PIC in the closed state · an experimental structure of the same protein · chain A against 1, TM-score 0.57
• 8EBV · Initial DNA-lesion (AP) binding by XPC and TFIIH complex 1 · an experimental structure of the same protein · chain A against C, TM-score 0.52
• 8EBW · Initial DNA-lesion (AP) binding by XPC and TFIIH complex2 · an experimental structure of the same protein · chain A against C, TM-score 0.52
• 7NVY · RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position · an experimental structure of the same protein · chain A against 1, TM-score 0.45

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P32780
• Elsewhere: UniProt P32780 · AlphaFold DB P32780