MolNFT v1 · #436406 · protein
AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase src (P00523)
P00523: “AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase src (P00523)”. 6 pockets (best druggability 0.80). MolNFT v1 #436406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P00523
- Type
- protein
- Length
- 533 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x10CE6839fAB1d16e972AA2437070Dd76D75b7C48
- Molecule
- Proto-oncogene tyrosine-protein kinase src
- UniProt
- P00523
- Pockets
- 6 · best druggability 0.80
Structure
1 distinct chain · 25% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene tyrosine-protein kinase src | protein | 533 | 25% helix, 19% strand | P00523 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 931 | 0.80 | 0.82 | 76 | empty |
| 2 | 402 | 0.73 | 0.84 | 47 | empty |
| 3 | 228 | 0.60 | 0.80 | 31 | empty |
| 4 | 71 | 0.43 | 0.81 | 19 | empty |
| 5 | 63 | 0.31 | 0.75 | 15 | empty |
Compared structures
- 2PTK · Chicken src tyrosine kinase · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 3U4W · Src in complex with DNA-templated macrocyclic inhibitor MC4b · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 3GEQ · Structural basis for the chemical rescue of Src kinase activity · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 3DQW · c-Src kinase domain Thr338Ile mutant in complex with ATPgS · an experimental structure of the same protein · chain A against D, TM-score 0.46
- 3EN4 · Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.46
- 3DQX · chicken c-Src kinase domain in complex with ATPgS · an experimental structure of the same protein · chain A against B, TM-score 0.46
- 3EN5 · Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with… · an experimental structure of the same protein · chain A against B, TM-score 0.46
- 3G6H · Src Thr338Ile inhibited in the DFG-Asp-Out conformation · an experimental structure of the same protein · chain A against A, TM-score 0.45
- 3U51 · Src in complex with DNA-templated macrocyclic inhibitor MC1 · an experimental structure of the same protein · chain A against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00523
- Elsewhere: UniProt P00523 · AlphaFold DB P00523
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