MolNFT v1 · #431495 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (A2A5Z6)
A2A5Z6: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SMURF2 (A2A5Z6)”. 10 pockets (best druggability 0.80). MolNFT v1 #431495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- A2A5Z6
- Type
- protein
- Length
- 748 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB44F19a0cb161828322eEEd13F55d4C3C34938d2
- Molecule
- E3 ubiquitin-protein ligase SMURF2
- UniProt
- A2A5Z6
- Pockets
- 10 · best druggability 0.80
Structure
1 distinct chain · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase SMURF2 | protein | 748 | 32% helix, 21% strand | A2A5Z6 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 861 | 0.80 | 0.83 | 81 | empty |
| 2 | 873 | 0.74 | 0.78 | 57 | empty |
| 3 | 237 | 0.62 | 0.81 | 39 | empty |
| 4 | 95 | 0.56 | 0.85 | 18 | empty |
| 5 | 99 | 0.47 | 0.80 | 15 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2A5Z6
- Elsewhere: UniProt A2A5Z6 · AlphaFold DB A2A5Z6
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