MolNFT v1 · #431310 · protein
AlphaFold monomer V2.0 prediction for protein smoothened (P91682)
P91682: “AlphaFold monomer V2.0 prediction for protein smoothened (P91682)”. 5 pockets (best druggability 0.84). MolNFT v1 #431310 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P91682
- Type
- protein
- Length
- 1,036 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xEa58c7534E5701aA8370E0fAEb19b7e14653e69c
- Molecule
- Protein smoothened
- UniProt
- P91682
- Pockets
- 5 · best druggability 0.84
Structure
1 distinct chain · 41% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein smoothened | protein | 1036 | 41% helix, 5% strand | P91682 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.84 | 0.85 | 80 | empty |
| 2 | 944 | 0.73 | 0.77 | 85 | empty |
| 3 | 66 | 0.54 | 0.87 | 19 | empty |
| 4 | 71 | 0.35 | 0.76 | 13 | empty |
| 5 | 85 | 0.32 | 0.73 | 17 | empty |
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 2MAH · Solution structure of Smoothened · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 2MAH · Solution structure of smoothened · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 8OIJ · Drosophila Smaug-Smoothened complex · an experimental structure of the same protein · chain A against C, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P91682
- Elsewhere: UniProt P91682 · AlphaFold DB P91682
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