MolNFT v1 · #430262 · protein
AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWF5 (O59800)
O59800: “AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWF5 (O59800)”. 4 pockets (best druggability 0.59). MolNFT v1 #430262 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O59800
- Type
- protein
- Length
- 354 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB0d7400b9DcfaC79853F2a70119e45D7974F7358
- Molecule
- Pre-mRNA-splicing factor CWF5
- UniProt
- O59800
- Pockets
- 4 · best druggability 0.59
Structure
1 distinct chain · 31% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-splicing factor CWF5 | protein | 354 | 31% helix, 17% strand | O59800 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.59 | 0.79 | 29 | empty |
| 2 | 52 | 0.44 | 0.84 | 19 | empty |
| 3 | 66 | 0.37 | 0.78 | 17 | empty |
| 4 | 74 | 0.31 | 0.74 | 19 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 9ESH · Structure of a B-state intermediate committed to discard (Bd-I state) · an experimental structure of the same protein · chain A against M, TM-score 0.63
- 9ESI · Structure of a B-state intermediate committed to discard (Bd-II state) · an experimental structure of the same protein · chain A against M, TM-score 0.63
- 3JB9 · Cryo-EM structure of the yeast spliceosome at 3.6 ångström resolution · an experimental structure of the same protein · chain A against a, TM-score 0.59
- 3JB9 · Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution · an experimental structure of the same protein · chain A against a, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59800
- Elsewhere: UniProt O59800 · AlphaFold DB O59800
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