MolNFT v1 · #429355 · protein

AlphaFold monomer V2.0 prediction for E3 sumo-protein ligase SIZ1 (Q680Q4)

Q680Q4: “AlphaFold monomer V2.0 prediction for E3 sumo-protein ligase SIZ1 (Q680Q4)”. 7 pockets (best druggability 0.51). MolNFT v1 #429355 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q680Q4
Type: protein
Length: 884 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xd1A2963012bEcbC7A8f505464439Ab678C48936f
Molecule: E3 sumo-protein ligase SIZ1
UniProt: Q680Q4
Pockets: 7 · best druggability 0.51

Structure

1 distinct chain · 16% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 sumo-protein ligase SIZ1	protein	884	16% helix, 12% strand	Q680Q4

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.51	0.77	24	empty
2	130	0.44	0.76	17	empty
3	121	0.38	0.74	24	empty
4	58	0.33	0.77	13	empty
5	52	0.32	0.78	13	empty

Compared structures

1WEW · Solution structure of phd domain in DNA-binding family protein AAM98074 · an experimental structure of the same protein · chain A against A, TM-score 0.07
1WEW · Solution structure of PHD domain in DNA-binding family protein AAM98074 · an experimental structure of the same protein · chain A against A, TM-score 0.07

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q680Q4
Elsewhere: UniProt Q680Q4 · AlphaFold DB Q680Q4

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