MolNFT v1 · #425793 · protein

AlphaFold monomer V2.0 prediction for semaphorin-1A (Q24322)

Q24322: “AlphaFold monomer V2.0 prediction for semaphorin-1A (Q24322)”. 7 pockets (best druggability 0.72). MolNFT v1 #425793 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q24322
Type: protein
Length: 899 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x661f92Fc5950020C7aB410B5F5b9a3f429F49Ae5
Molecule: Semaphorin-1A
UniProt: Q24322
Pockets: 7 · best druggability 0.72

Structure

1 distinct chain · 14% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Semaphorin-1A	protein	899	14% helix, 25% strand	Q24322

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	709	0.72	0.79	61	empty
2	51	0.62	0.93	11	empty
3	133	0.46	0.77	18	empty
4	229	0.45	0.73	28	empty
5	147	0.43	0.75	19	empty

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

6QP9 · Drosophila semaphorin 1A, extracellular domains 1-2 · an experimental structure of the same protein · chain A against A, TM-score 0.54
6QP9 · Drosophila Semaphorin 1a, extracellular domains 1-2 · an experimental structure of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q24322
Elsewhere: UniProt Q24322 · AlphaFold DB Q24322

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