MolNFT v1 · #422605 · protein
AlphaFold monomer V2.0 prediction for UBIQUITINATING/DEUBIQUITINATING enzyme sdea (Q5ZTK4)
Q5ZTK4: “AlphaFold monomer V2.0 prediction for UBIQUITINATING/DEUBIQUITINATING enzyme sdea (Q5ZTK4)”. 17 pockets (best druggability 0.78). MolNFT v1 #422605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q5ZTK4
- Type
- protein
- Length
- 1,499 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xe6978154f003B8CE0AC2dEd3c6fdD559315c6935
- Molecule
- UBIQUITINATING/DEUBIQUITINATING enzyme sdea
- UniProt
- Q5ZTK4
- Pockets
- 17 · best druggability 0.78
Structure
1 distinct chain · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UBIQUITINATING/DEUBIQUITINATING enzyme sdea | protein | 1499 | 58% helix, 8% strand | Q5ZTK4 |
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.78 | 0.80 | 91 | empty |
| 2 | 349 | 0.72 | 0.84 | 54 | empty |
| 3 | 188 | 0.69 | 0.87 | 24 | empty |
| 4 | 301 | 0.60 | 0.78 | 32 | empty |
| 5 | 270 | 0.55 | 0.76 | 37 | empty |
Compared structures
- 7MIR · Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex · an experimental structure of the same protein · chain A against C, TM-score 0.48
- 7MIR · Cryo-EM structure of sidj-sdea-cam reaction intermediate complex · an experimental structure of the same protein · chain A against C, TM-score 0.48
- 7PPO · Structure of SIDJ/CAM bound to sdea in pre-glutamylation state · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 7PPO · Structure of SidJ/CaM bound to SdeA in pre-glutamylation state · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 7PQE · Structure of SidJ/CaM bound to SdeA in post-catalysis state · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 7PQE · Structure of SIDJ/CAM bound to sdea in post-catalysis state · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 6G0C · Crystal structure of sdea catalytic core · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 6G0C · Crystal structure of SdeA catalytic core · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 6WTG · Sdea dub domain in complex with ubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 6WTG · SdeA DUB Domain in complex with Ubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 5YSJ · SdeA mART-C domain WT apo · an experimental structure of the same protein · chain A against D, TM-score 0.09
- 5YSJ · Sdea mart-C domain wt apo · an experimental structure of the same protein · chain A against D, TM-score 0.09
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZTK4
- Elsewhere: UniProt Q5ZTK4 · AlphaFold DB Q5ZTK4
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