MolNFT v1 · #421575 · protein
AlphaFold monomer V2.0 prediction for amiloride-sensitive sodium channel subunit alpha (O97741)
O97741: “AlphaFold monomer V2.0 prediction for amiloride-sensitive sodium channel subunit alpha (O97741)”. 10 pockets (best druggability 0.67). MolNFT v1 #421575 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O97741
- Type
- protein
- Length
- 640 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x84C29Ef3da704f3F8077E18d9E11eBbbA2488271
- Molecule
- Amiloride-sensitive sodium channel subunit alpha
- UniProt
- O97741
- Pockets
- 10 · best druggability 0.67
Structure
1 distinct chain · 30% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amiloride-sensitive sodium channel subunit alpha | protein | 640 | 30% helix, 19% strand | O97741 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 557 | 0.67 | 0.77 | 47 | empty |
| 2 | 327 | 0.57 | 0.76 | 27 | empty |
| 3 | 312 | 0.52 | 0.74 | 37 | empty |
| 4 | 92 | 0.50 | 0.82 | 13 | empty |
| 5 | 61 | 0.37 | 0.78 | 12 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O97741
- Elsewhere: UniProt O97741 · AlphaFold DB O97741
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