MolNFT v1 · #421523 · protein

AlphaFold monomer V2.0 prediction for sodium channel protein type 8 subunit alpha (Q9WTU3)

Q9WTU3: “AlphaFold monomer V2.0 prediction for sodium channel protein type 8 subunit alpha (Q9WTU3)”. 20 pockets (best druggability 0.84). MolNFT v1 #421523 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9WTU3
Type: protein
Length: 1,978 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xc0F878C3f3E2a1874e2A6daC80d429e553DdB0D5
Molecule: Sodium channel protein type 8 subunit alpha
UniProt: Q9WTU3
Pockets: 20 · best druggability 0.84

Structure

1 distinct chain · 54% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sodium channel protein type 8 subunit alpha	protein	1978	54% helix, 3% strand	Q9WTU3

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1184	0.84	0.85	78	empty
2	1007	0.75	0.77	74	empty
3	919	0.75	0.78	73	empty
4	431	0.68	0.79	48	empty
5	526	0.68	0.78	42	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3WFN · Crystal structure of NAV1.6 iq motif in complex with apo-cam · an experimental structure of the same protein · chain A against E, TM-score 0.06
3WFN · Crystal Structure of Nav1.6 IQ motif in complex with apo-CaM · an experimental structure of the same protein · chain A against E, TM-score 0.06

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WTU3
Elsewhere: UniProt Q9WTU3 · AlphaFold DB Q9WTU3

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