MolNFT v1 · #421513 · protein
AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit alpha (P15390)
P15390: “AlphaFold monomer V2.0 prediction for sodium channel protein type 4 subunit alpha (P15390)”. 20 pockets (best druggability 0.86). MolNFT v1 #421513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P15390
- Type
- protein
- Length
- 1,840 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9188600a0FCa2914254C94299b1bd9721Bc4D500
- Molecule
- Sodium channel protein type 4 subunit alpha
- UniProt
- P15390
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 4 subunit alpha | protein | 1840 | 58% helix, 3% strand | P15390 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1069 | 0.86 | 0.86 | 91 | empty |
| 2 | 1009 | 0.77 | 0.79 | 94 | empty |
| 3 | 609 | 0.72 | 0.79 | 55 | empty |
| 4 | 845 | 0.69 | 0.75 | 65 | empty |
| 5 | 50 | 0.67 | 0.96 | 16 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 5JR0 · Domain 4 segment 6 of voltage-gated sodium channel NAV1.4 · an experimental structure of the same protein · chain A against A, TM-score 0.02
- 6MUE · Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 6MUE · Voltage-gated sodium channel NAV1.4 iq domain in complex with CA2+/CALMODULIN · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15390
- Elsewhere: UniProt P15390 · AlphaFold DB P15390
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