MolNFT v1 · #421482 · protein

AlphaFold monomer V2.0 prediction for sodium channel protein type 1 subunit alpha (P35498)

P35498: “AlphaFold monomer V2.0 prediction for sodium channel protein type 1 subunit alpha (P35498)”. 20 pockets (best druggability 0.86). MolNFT v1 #421482 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P35498
Type: protein
Length: 2,009 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xbb2F1C7CB3A1eeFAc24fCa72cc627162D5413FD7
Molecule: Sodium channel protein type 1 subunit alpha
UniProt: P35498
Pockets: 20 · best druggability 0.86

Structure

1 distinct chain · 54% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sodium channel protein type 1 subunit alpha	protein	2009	54% helix, 4% strand	P35498

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1154	0.86	0.86	96	empty
2	830	0.74	0.78	66	empty
3	1198	0.74	0.77	86	empty
4	495	0.67	0.79	44	empty
5	277	0.64	0.81	38	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

7DTD · Voltage-gated sodium channel Nav1.1 and beta4 · an experimental structure of the same protein · chain A against A, TM-score 0.56
7DTD · Voltage-gated sodium channel NAV1.1 and BETA4 · an experimental structure of the same protein · chain A against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35498
Elsewhere: UniProt P35498 · AlphaFold DB P35498

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