MolNFT v1 · #421215 · protein

AlphaFold monomer V2.0 prediction for cohesin subunit SCC3 (P40541)

P40541: “AlphaFold monomer V2.0 prediction for cohesin subunit SCC3 (P40541)”. 12 pockets (best druggability 0.56). MolNFT v1 #421215 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P40541
Type: protein
Length: 1,150 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x78Cc7f9BF18AF8279e492D45EE7Fe9d7cC6f6D07
Molecule: Cohesin subunit SCC3
UniProt: P40541
Pockets: 12 · best druggability 0.56

Structure

1 distinct chain · 57% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cohesin subunit SCC3	protein	1150	57% helix, 1% strand	P40541

Pockets

12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	298	0.56	0.76	31	empty
2	181	0.48	0.76	26	empty
3	76	0.44	0.81	14	empty
4	55	0.43	0.82	17	empty
5	80	0.41	0.79	19	empty

Compared structures

6H8Q · Structural basis for SCC3-dependent cohesin recruitment to chromatin · an experimental structure of the same protein · chain A against A, TM-score 0.74
6H8Q · Structural basis for Scc3-dependent cohesin recruitment to chromatin · an experimental structure of the same protein · chain A against A, TM-score 0.74
4UVJ · Cohesin subunit Scc3 from yeast, 674-1072 · an experimental structure of the same protein · chain A against A, TM-score 0.30
4UVJ · Cohesin subunit SCC3 from yeast, 674-1072 · an experimental structure of the same protein · chain A against A, TM-score 0.30

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40541
Elsewhere: UniProt P40541 · AlphaFold DB P40541

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