MolNFT v1 · #421051 · protein
AlphaFold monomer V2.0 prediction for sodium- and chloride-dependent GABA transporter 1 (P23978)
P23978: “AlphaFold monomer V2.0 prediction for sodium- and chloride-dependent GABA transporter 1 (P23978)”. 4 pockets (best druggability 0.77). MolNFT v1 #421051 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P23978
- Type
- protein
- Length
- 599 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xa73BAb1DabE4333A884D03393eAa10c3B4215494
- Molecule
- Sodium- and chloride-dependent GABA transporter 1
- UniProt
- P23978
- Pockets
- 4 · best druggability 0.77
Structure
1 distinct chain · 66% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium- and chloride-dependent GABA transporter 1 | protein | 599 | 66% helix, 2% strand | P23978 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.77 | 0.81 | 82 | empty |
| 2 | 166 | 0.46 | 0.76 | 33 | empty |
| 3 | 58 | 0.42 | 0.82 | 17 | empty |
| 4 | 61 | 0.35 | 0.77 | 13 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 8GNK · CryoEM structure of cytosol-facing, substrate-bound ratGAT1 · an experimental structure of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23978
- Elsewhere: UniProt P23978 · AlphaFold DB P23978
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