MolNFT v1 · #386890 · protein

AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (P06269)

P06269: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (P06269)”. 5 pockets (best druggability 0.53). MolNFT v1 #386890 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P06269
Type: protein
Length: 337 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x78Cc7f9BF18AF8279e492D45EE7Fe9d7cC6f6D07
Molecule: DNA-directed RNA polymerase subunit alpha
UniProt: P06269
Pockets: 5 · best druggability 0.53

Structure

1 distinct chain · 31% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-directed RNA polymerase subunit alpha	protein	337	31% helix, 30% strand	P06269

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.53	0.81	17	empty
2	56	0.48	0.86	20	empty
3	148	0.45	0.75	22	empty
4	60	0.29	0.74	18	empty
5	52	0.27	0.73	11	empty

Compared structures

8W9Z · The cryo-EM structure of the Nicotiana tabacum PEP-PAP · an experimental structure of the same protein · chain A against a, TM-score 0.66
8WA1 · The cryo-EM structure of the Nicotiana tabacum PEP-PAP-TEC2 · an experimental structure of the same protein · chain A against a, TM-score 0.66
8WA0 · The cryo-EM structure of the Nicotiana tabacum PEP-PAP-TEC1 · an experimental structure of the same protein · chain A against a, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06269
Elsewhere: UniProt P06269 · AlphaFold DB P06269

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