MolNFT v1 · #385062 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC2 (Q9NW08)
Q9NW08: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC2 (Q9NW08)”. 16 pockets (best druggability 0.76). MolNFT v1 #385062 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9NW08
- Type
- protein
- Length
- 1,133 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9188600a0FCa2914254C94299b1bd9721Bc4D500
- Molecule
- DNA-directed RNA polymerase III subunit RPC2
- UniProt
- Q9NW08
- Pockets
- 16 · best druggability 0.76
Structure
1 distinct chain · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase III subunit RPC2 | protein | 1133 | 30% helix, 26% strand | Q9NW08 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 784 | 0.76 | 0.80 | 72 | empty |
| 2 | 56 | 0.63 | 0.94 | 22 | empty |
| 3 | 254 | 0.55 | 0.77 | 26 | empty |
| 4 | 180 | 0.53 | 0.79 | 22 | empty |
| 5 | 262 | 0.49 | 0.74 | 27 | empty |
Compared structures
- 8ITY · human RNA polymerase III pre-initiation complex closed DNA 1 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 8IUE · RNA polymerase III pre-initiation complex melting complex 1 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7A6H · Cryo-EM structure of human apo RNA Polymerase III · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7A6H · Cryo-EM structure of human apo RNA polymerase III · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7AE3 · Cryo-EM structure of human RNA polymerase III elongation complex 3 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7AE3 · Cryo-EM structure of human RNA Polymerase III elongation complex 3 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7FJI · Human pol III elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7FJI · human Pol III elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7AE1 · Cryo-EM structure of human RNA Polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7AE1 · Cryo-EM structure of human RNA polymerase III elongation complex 1 · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7FJJ · Human pol III pre-termination complex · an experimental structure of the same protein · chain A against B, TM-score 0.96
- 7FJJ · human Pol III pre-termination complex · an experimental structure of the same protein · chain A against B, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NW08
- Elsewhere: UniProt Q9NW08 · AlphaFold DB Q9NW08
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