MolNFT v1 · #384987 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P36594)
P36594: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB1 (P36594)”. 19 pockets (best druggability 0.74). MolNFT v1 #384987 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P36594
- Type
- protein
- Length
- 1,752 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xBeB220F0B5b0C48F46B5DDd3E3b071BC0827f8D6
- Molecule
- DNA-directed RNA polymerase II subunit RPB1
- UniProt
- P36594
- Pockets
- 19 · best druggability 0.74
Structure
1 distinct chain · 34% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase II subunit RPB1 | protein | 1752 | 34% helix, 13% strand | P36594 |
Pockets
19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 844 | 0.74 | 0.78 | 94 | empty |
| 2 | 797 | 0.71 | 0.77 | 62 | empty |
| 3 | 590 | 0.68 | 0.77 | 66 | empty |
| 4 | 91 | 0.68 | 0.92 | 25 | empty |
| 5 | 400 | 0.64 | 0.78 | 41 | empty |
Compared structures
- 8QSZ · Structure of s. pombe RNA polymerase II in complex with DSIF and Rat1/Rai1 · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 3H0G · RNA Polymerase II from Schizosaccharomyces pombe · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 3H0G · RNA polymerase II from schizosaccharomyces pombe · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 5U0S · Cryo-EM structure of the Mediator-RNAPII complex · an experimental structure of the same protein · chain A against a, TM-score 0.80
- 5U0S · Cryo-EM structure of the mediator-rnapii complex · an experimental structure of the same protein · chain A against a, TM-score 0.80
- 4PZ6 · PCE1 guanylyltransferase bound to SER2/SER5 phosphorylated RNA pol II CTD · an experimental structure of the same protein · chain A against P, TM-score 0.00
- 4PZ6 · PCE1 guanylyltransferase bound to SER2/SER5 phosphorylated RNA pol II ctd · an experimental structure of the same protein · chain A against P, TM-score 0.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36594
- Elsewhere: UniProt P36594 · AlphaFold DB P36594
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