MolNFT v1 · #381238 · protein
AlphaFold monomer V2.0 prediction for RAS GTPase-activating-like protein RNG2 (O14188)
O14188: “AlphaFold monomer V2.0 prediction for RAS GTPase-activating-like protein RNG2 (O14188)”. 13 pockets (best druggability 0.68). MolNFT v1 #381238 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O14188
- Type
- protein
- Length
- 1,489 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xcbd6C743Abc67aE89D40a6eAd06465a8c4D0789f
- Molecule
- RAS GTPase-activating-like protein RNG2
- UniProt
- O14188
- Pockets
- 13 · best druggability 0.68
Structure
1 distinct chain · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS GTPase-activating-like protein RNG2 | protein | 1489 | 65% helix, 3% strand | O14188 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 593 | 0.68 | 0.77 | 49 | empty |
| 2 | 528 | 0.66 | 0.77 | 45 | empty |
| 3 | 226 | 0.61 | 0.81 | 30 | empty |
| 4 | 132 | 0.53 | 0.81 | 22 | empty |
| 5 | 257 | 0.51 | 0.75 | 33 | empty |
Compared structures
- 1P2X · Crystal structure of the calponin-homology domain of RNG2 from schizosaccharomyces pombe · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 1P2X · Crystal structure of the calponin-homology domain of RNG2 from schizosaccharomyces pombe · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 1P5S · Structure and function of the calponin-homology domain of an iqgap protein from… · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 1P5S · Structure and function of the calponin-homology domain of an iqgap protein from… · an experimental structure of the same protein · chain A against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14188
- Elsewhere: UniProt O14188 · AlphaFold DB O14188
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