MolNFT v1 · #342583 · protein

AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 25 (P42331)

P42331: “AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 25 (P42331)”. 3 pockets (best druggability 0.45). MolNFT v1 #342583 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P42331
Type: protein
Length: 645 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x7fe803A1694E5884a4149b96391e1F40D0875b54
Molecule: Rho GTPase-activating protein 25
UniProt: P42331
Pockets: 3 · best druggability 0.45

Structure

1 distinct chain · 37% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho GTPase-activating protein 25	protein	645	37% helix, 6% strand	P42331

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.45	0.82	24	empty
2	82	0.34	0.75	13	empty
3	58	0.28	0.74	15	empty

Compared structures

1V89 · Solution Structure of the Pleckstrin Homology Domain of Human KIAA0053 Protein · an experimental structure of the same protein · chain A against A, TM-score 0.16
1V89 · Solution structure of the pleckstrin homology domain of human KIAA0053 protein · an experimental structure of the same protein · chain A against A, TM-score 0.16

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42331
Elsewhere: UniProt P42331 · AlphaFold DB P42331

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