AlphaFold monomer V2.0 prediction for GTPase KRAS (P01116)

Structure

1 distinct chain · 40% helix, 25% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4DSO · Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated… · an experimental structure of the same protein · chain A against A, TM-score 0.91
• 4DSN · Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated… · an experimental structure of the same protein · chain A against A, TM-score 0.91
• 4DST · Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated… · an experimental structure of the same protein · chain A against A, TM-score 0.91
• 7RSE · NMR-driven structure of the KRAS4B-G12D alpha-beta" dimer on a lipid bilayer nanodisc" · an experimental structure of the same protein · chain A against A, TM-score 0.90
• 2MSE · NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer… · an experimental structure of the same protein · chain A against B, TM-score 0.90
• 6W4E · NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc · an experimental structure of the same protein · chain A against C, TM-score 0.90
• 7RSC · NMR-driven structure of the KRAS4B-G12D alpha-alpha" dimer on a lipid bilayer nanodisc" · an experimental structure of the same protein · chain A against B, TM-score 0.89
• 6GOF · KRAS full length G12D GPPNHP · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 6GOD · KRAS full length wild-type GPPNHP · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 8T74 · Crystal structure of KRAS4a (GMPPNP) in complex with RAF1 (RBD) · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 5OCG · Discovery of small molecules binding to KRAS via high affinity antibody fragment… · an experimental structure of the same protein · chain A against A, TM-score 0.89
• 7SCW · KRAS full length wild-type in complex with RGL1 Ras association domain · an experimental structure of the same protein · chain A against A, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01116
• Elsewhere: UniProt P01116 · AlphaFold DB P01116