MolNFT v1 · #332237 · protein
AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase (Q99N57)
Q99N57: “AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase (Q99N57)”. 7 pockets (best druggability 0.76). MolNFT v1 #332237 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q99N57
- Type
- protein
- Length
- 648 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x429aA010A80A47FF4a2777bB34A2bba144d19df2
- Molecule
- RAF proto-oncogene SERINE/THREONINE-protein kinase
- UniProt
- Q99N57
- Pockets
- 7 · best druggability 0.76
Structure
1 distinct chain · 23% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAF proto-oncogene SERINE/THREONINE-protein kinase | protein | 648 | 23% helix, 15% strand | Q99N57 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 448 | 0.76 | 0.85 | 54 | empty |
| 2 | 786 | 0.74 | 0.79 | 83 | empty |
| 3 | 279 | 0.51 | 0.74 | 39 | empty |
| 4 | 72 | 0.43 | 0.80 | 18 | empty |
| 5 | 182 | 0.43 | 0.73 | 25 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99N57
- Elsewhere: UniProt Q99N57 · AlphaFold DB Q99N57
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