MolNFT v1 · #318378 · protein
AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten (O08586)
O08586: “AlphaFold monomer V2.0 prediction for phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and…”. 4 pockets (best druggability 0.75). MolNFT v1 #318378 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O08586
- Type
- protein
- Length
- 403 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xdF2b063d4B94F3f46D117B1af99A846bD4a59284
- Molecule
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein…
- UniProt
- O08586
- Pockets
- 4 · best druggability 0.75
Structure
1 distinct chain · 25% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten | protein | 403 | 25% helix, 29% strand | O08586 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 921 | 0.75 | 0.79 | 81 | empty |
| 2 | 181 | 0.54 | 0.79 | 30 | empty |
| 3 | 144 | 0.54 | 0.81 | 22 | empty |
| 4 | 98 | 0.52 | 0.83 | 17 | empty |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08586
- Elsewhere: UniProt O08586 · AlphaFold DB O08586
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