MolNFT v1 · #318157 · protein

AlphaFold monomer V2.0 prediction for phosphoenolpyruvate-protein phosphotransferase (P51183)

P51183: “AlphaFold monomer V2.0 prediction for phosphoenolpyruvate-protein phosphotransferase (P51183)”. 6 pockets (best druggability 0.71). MolNFT v1 #318157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P51183
Type: protein
Length: 572 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xEfa66a179B0bfB1956708792b71f4aa3D23c60e2
Molecule: Phosphoenolpyruvate-protein phosphotransferase
UniProt: P51183
Pockets: 6 · best druggability 0.71

Structure

1 distinct chain · 52% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoenolpyruvate-protein phosphotransferase	protein	572	52% helix, 15% strand	P51183

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1163	0.71	0.75	89	empty
2	107	0.50	0.82	29	empty
3	167	0.44	0.75	20	empty
4	106	0.39	0.75	16	empty
5	78	0.35	0.75	12	empty

Compared structures

2WQD · Crystal structure of enzyme I of the PHOSPHOENOLPYRUVATE:SUGAR phosphotransferase system… · an experimental structure of the same protein · chain A against A, TM-score 0.96
2WQD · Crystal structure of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system… · an experimental structure of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51183
Elsewhere: UniProt P51183 · AlphaFold DB P51183

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