MolNFT v1 · #306461 · protein
AlphaFold monomer V2.0 prediction for phosphopantothenate--cysteine ligase CAB2 (P40506)
P40506: “AlphaFold monomer V2.0 prediction for phosphopantothenate--cysteine ligase CAB2 (P40506)”. 6 pockets (best druggability 0.78). MolNFT v1 #306461 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P40506
- Type
- protein
- Length
- 365 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9073C46348542FfE4327c3F363F9B51B22058e75
- Molecule
- Phosphopantothenate--cysteine ligase CAB2
- UniProt
- P40506
- Pockets
- 6 · best druggability 0.78
Structure
1 distinct chain · 36% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphopantothenate--cysteine ligase CAB2 | protein | 365 | 36% helix, 18% strand | P40506 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 738 | 0.78 | 0.82 | 61 | empty |
| 2 | 129 | 0.53 | 0.81 | 23 | empty |
| 3 | 143 | 0.44 | 0.76 | 28 | empty |
| 4 | 75 | 0.36 | 0.76 | 17 | empty |
| 5 | 71 | 0.33 | 0.74 | 12 | empty |
Compared structures
- 6AI9 · Cab2 mutant-H337A complex with phosphopantothenate · an experimental structure of the same protein · chain A against B, TM-score 0.85
- 6AI9 · CAB2 mutant-H337A complex with phosphopantothenate · an experimental structure of the same protein · chain A against B, TM-score 0.85
- 6AIK · CAB2 mutant H337A complex with phosphopantothenoyl-cmp · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6AIK · Cab2 mutant H337A complex with phosphopantothenoyl-CMP · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6AIP · Cab2 mutant-H337A complex with phosphopantothenoylcystine · an experimental structure of the same protein · chain A against B, TM-score 0.85
- 6AIP · CAB2 mutant-H337A complex with phosphopantothenoylcystine · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 6AIM · CAB2 mutant H337A complex with phosphopantothenate-cysteine · an experimental structure of the same protein · chain A against B, TM-score 0.84
- 6AIM · Cab2 mutant H337A complex with phosphopantothenate-cysteine · an experimental structure of the same protein · chain A against B, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40506
- Elsewhere: UniProt P40506 · AlphaFold DB P40506
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