MolNFT v1 · #306448 · protein

AlphaFold monomer V2.0 prediction for prolyl endopeptidase (P48147)

P48147: “AlphaFold monomer V2.0 prediction for prolyl endopeptidase (P48147)”. 7 pockets (best druggability 0.74). MolNFT v1 #306448 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P48147
Type: protein
Length: 710 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x362a6d063b1B7E1B6EfD3A9A7CA3612e3FE037AA
Molecule: Prolyl endopeptidase
UniProt: P48147
Pockets: 7 · best druggability 0.74

Structure

1 distinct chain · 23% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prolyl endopeptidase	protein	710	23% helix, 33% strand	P48147

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	772	0.74	0.79	69	empty
2	727	0.72	0.78	62	empty
3	103	0.48	0.80	20	empty
4	109	0.39	0.75	19	empty
5	77	0.36	0.76	14	empty

Compared structures

3DDU · Prolyl Oligopeptidase with GSK552 · an experimental structure of the same protein · chain A against A, TM-score 0.99
3DDU · Prolyl oligopeptidase with GSK552 · an experimental structure of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48147
Elsewhere: UniProt P48147 · AlphaFold DB P48147

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