MolNFT v1 · #303019 · protein
AlphaFold monomer V2.0 prediction for plexin-C1 (O60486)
O60486: “AlphaFold monomer V2.0 prediction for plexin-C1 (O60486)”. 20 pockets (best druggability 0.74). MolNFT v1 #303019 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O60486
- Type
- protein
- Length
- 1,568 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9B130d619fCFc21d0D08E5Ce38Cf42A5fbe230CB
- Molecule
- Plexin-C1
- UniProt
- O60486
- Pockets
- 20 · best druggability 0.74
Structure
1 distinct chain · 27% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plexin-C1 | protein | 1568 | 27% helix, 30% strand | O60486 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.74 | 0.77 | 89 | empty |
| 2 | 665 | 0.72 | 0.79 | 58 | empty |
| 3 | 380 | 0.59 | 0.76 | 37 | empty |
| 4 | 269 | 0.56 | 0.77 | 28 | empty |
| 5 | 201 | 0.53 | 0.78 | 19 | empty |
Modifications
Observed in the structure: 19 disulfide (disulfide).
Compared structures
- 6VXK · Cryo-EM structure of the full-length A39R/PLEXINC1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.45
- 3NVQ · Molecular mechanism of guidance cue recognition · an experimental structure of the same protein · chain A against B, TM-score 0.29
- 3NVQ · Molecular mechanism of guidance cue recognition · an experimental structure of the same protein · chain A against B, TM-score 0.29
- 3NVN · Molecular mechanism of guidance cue recognition · an experimental structure of the same protein · chain A against B, TM-score 0.29
- 3NVN · Molecular mechanism of guidance cue recognition · an experimental structure of the same protein · chain A against B, TM-score 0.29
- 3KUZ · Crystal structure of the ubiquitin like domain of PLXNC1 · an experimental structure of the same protein · chain A against A, TM-score 0.07
- 3KUZ · Crystal structure of the ubiquitin like domain of PLXNC1 · an experimental structure of the same protein · chain A against A, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60486
- Elsewhere: UniProt O60486 · AlphaFold DB O60486
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