MolNFT v1 · #303000 · protein

AlphaFold monomer V2.0 prediction for plexin-A1 (Q9UIW2)

Q9UIW2: “AlphaFold monomer V2.0 prediction for plexin-A1 (Q9UIW2)”. 15 pockets (best druggability 0.79). MolNFT v1 #303000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9UIW2
Type: protein
Length: 1,896 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5fC9aBB8Bc9CF27cFb3589c392399183ca519d77
Molecule: Plexin-A1
UniProt: Q9UIW2
Pockets: 15 · best druggability 0.79

Structure

1 distinct chain · 26% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plexin-A1	protein	1896	26% helix, 30% strand	Q9UIW2

Pockets

15 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	990	0.79	0.80	92	empty
2	811	0.78	0.82	78	empty
3	898	0.70	0.76	54	empty
4	143	0.47	0.78	22	empty
5	161	0.44	0.75	19	empty

Modifications

Observed in the structure: 24 disulfide (disulfide).

Compared structures

7Y4P · Human Plexin A1, extracellular domains 1-4 · an experimental structure of the same protein · chain A against A, TM-score 0.35
7Y4Q · Semaphorin 6D in complex with Plexin A1 · an experimental structure of the same protein · chain A against A, TM-score 0.35

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UIW2
Elsewhere: UniProt Q9UIW2 · AlphaFold DB Q9UIW2

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