MolNFT v1 · #300598 · protein

AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pkna (P9WI83)

P9WI83: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase pkna (P9WI83)”. 2 pockets (best druggability 0.74). MolNFT v1 #300598 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P9WI83
Type: protein
Length: 431 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xbb2F1C7CB3A1eeFAc24fCa72cc627162D5413FD7
Molecule: SERINE/THREONINE-protein kinase pkna
UniProt: P9WI83
Pockets: 2 · best druggability 0.74

Structure

1 distinct chain · 32% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase pkna	protein	431	32% helix, 12% strand	P9WI83

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	501	0.74	0.83	64	empty
2	70	0.35	0.76	14	empty

Compared structures

4X3F · Crystal structure of the intracellular domain of the M. tuberculosis Ser/Thr kinase PknA · an experimental structure of the same protein · chain A against B, TM-score 0.63
4X3F · Crystal structure of the intracellular domain of the M. tuberculosis SER/THR kinase pkna · an experimental structure of the same protein · chain A against B, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WI83
Elsewhere: UniProt P9WI83 · AlphaFold DB P9WI83

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