MolNFT v1 · #297858 · protein
AlphaFold monomer V2.0 prediction for phosphorylase B kinase gamma catalytic chain, skeletal MUSCLE/HEART isoform (P00518)
P00518: “AlphaFold monomer V2.0 prediction for phosphorylase B kinase gamma catalytic chain, skeletal MUSCLE/HEART…”. 3 pockets (best druggability 0.72). MolNFT v1 #297858 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P00518
- Type
- protein
- Length
- 387 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x931f6ee42097C0611b7f12a7b3a279ef973b9cf4
- Molecule
- Phosphorylase B kinase gamma catalytic chain, skeletal MUSCLE/HEART isoform
- UniProt
- P00518
- Pockets
- 3 · best druggability 0.72
Structure
1 distinct chain · 44% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphorylase B kinase gamma catalytic chain, skeletal MUSCLE/HEART isoform | protein | 387 | 44% helix, 14% strand | P00518 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 605 | 0.72 | 0.79 | 49 | empty |
| 2 | 186 | 0.50 | 0.77 | 30 | empty |
| 3 | 147 | 0.46 | 0.76 | 21 | empty |
Compared structures
- 1QL6 · The catalytic mechanism of phosphorylase kinase probed by mutational studies · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1QL6 · The catalytic mechanism of phosphorylase kinase probed by mutational studies · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 1PHK · Two structures of the catalytic domain of phosphorylase, kinase: an active protein kinase… · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 1PHK · Two structures of the catalytic domain of phosphorylase, kinase: an active protein kinase… · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 2PHK · The crystal structure of a phosphorylase kinase peptide substrate complex: kinase… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 2PHK · The crystal structure of a phosphorylase kinase peptide substrate complex: kinase… · an experimental structure of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00518
- Elsewhere: UniProt P00518 · AlphaFold DB P00518
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