MolNFT v1 · #290909 · protein
AlphaFold monomer V2.0 prediction for protein disulfide-isomerase (P55059)
P55059: “AlphaFold monomer V2.0 prediction for protein disulfide-isomerase (P55059)”. 3 pockets (best druggability 0.54). MolNFT v1 #290909 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P55059
- Type
- protein
- Length
- 505 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5Cc8336db6d496E3B01007Aa23AcE4A695b4613E
- Molecule
- Protein disulfide-isomerase
- UniProt
- P55059
- Pockets
- 3 · best druggability 0.54
Structure
1 distinct chain · 32% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein disulfide-isomerase | protein | 505 | 32% helix, 19% strand | P55059 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.54 | 0.76 | 30 | empty |
| 2 | 71 | 0.39 | 0.79 | 13 | empty |
| 3 | 71 | 0.32 | 0.74 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3WT1 · Crystal structure of the B'-a' domain of thermophilic fungal protein disulfide isomerase… · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 3WT1 · Crystal structure of the b'-a' domain of thermophilic fungal protein disulfide isomerase… · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 5CRW · Crystal structure of the b'-a' domain of oxidized protein disulfide isomerase complexed… · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 5CRW · Crystal structure of the B'-a' domain of oxidized protein disulfide isomerase complexed… · an experimental structure of the same protein · chain A against A, TM-score 0.47
- 3WT2 · Crystal structure of the B'-a' domain of thermophilic fungal protein disulfide isomerase… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 3WT2 · Crystal structure of the b'-a' domain of thermophilic fungal protein disulfide isomerase… · an experimental structure of the same protein · chain A against A, TM-score 0.40
- 2KP2 · Solution structure of the b' domain of thermophilic fungal protein disulfide isomerase · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 2KP2 · Solution structure of the B' domain of thermophilic fungal protein disulfide isomerase · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 2DJK · Solution structure of the b' domain of thermophilic fungal protein disulfide isomerase · an experimental structure of the same protein · chain A against A, TM-score 0.25
- 2DJK · Solution structure of the B' domain of thermophilic fungal protein disulfide isomerase · an experimental structure of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55059
- Elsewhere: UniProt P55059 · AlphaFold DB P55059
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