MolNFT v1 · #289131 · protein
AlphaFold monomer V2.0 prediction for pre-B-cell leukemia transcription factor 1 (P40424)
P40424: “AlphaFold monomer V2.0 prediction for pre-B-cell leukemia transcription factor 1 (P40424)”. 4 pockets (best druggability 0.48). MolNFT v1 #289131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P40424
- Type
- protein
- Length
- 430 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x35CE9E273dC599B97173f7Fa74880CacB153321E
- Molecule
- Pre-B-cell leukemia transcription factor 1
- UniProt
- P40424
- Pockets
- 4 · best druggability 0.48
Structure
1 distinct chain · 54% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-B-cell leukemia transcription factor 1 | protein | 430 | 54% helix, 0% strand | P40424 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.48 | 0.81 | 15 | empty |
| 2 | 109 | 0.39 | 0.75 | 21 | empty |
| 3 | 64 | 0.35 | 0.77 | 17 | empty |
| 4 | 52 | 0.24 | 0.72 | 11 | empty |
Compared structures
- 1B72 · PBX1, homeobox protein hox-B1/DNA ternary complex · an experimental structure of the same protein · chain A against B, TM-score 0.17
- 1B72 · PBX1, homeobox protein hox-B1/DNA ternary complex · an experimental structure of the same protein · chain A against B, TM-score 0.17
- 1PUF · Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 1PUF · Crystal structure of HOXA9 and PBX1 homeodomains bound to DNA · an experimental structure of the same protein · chain A against B, TM-score 0.16
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40424
- Elsewhere: UniProt P40424 · AlphaFold DB P40424
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