MolNFT v1 · #278998 · protein
AlphaFold monomer V2.0 prediction for 2'-5'-oligoadenylate synthase 1 (P00973)
P00973: “AlphaFold monomer V2.0 prediction for 2'-5'-oligoadenylate synthase 1 (P00973)”. 5 pockets (best druggability 0.71). MolNFT v1 #278998 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P00973
- Type
- protein
- Length
- 400 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x505a54e9c891975EBe9bE0abfDFa4150AA989521
- Molecule
- 2'-5'-oligoadenylate synthase 1
- UniProt
- P00973
- Pockets
- 5 · best druggability 0.71
Structure
1 distinct chain · 43% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2'-5'-oligoadenylate synthase 1 | protein | 400 | 43% helix, 13% strand | P00973 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.71 | 0.87 | 46 | empty |
| 2 | 562 | 0.67 | 0.77 | 48 | empty |
| 3 | 168 | 0.41 | 0.73 | 18 | empty |
| 4 | 111 | 0.40 | 0.76 | 17 | empty |
| 5 | 82 | 0.31 | 0.73 | 15 | empty |
Compared structures
- 4IG8 · Structural basis for cytosolic double-stranded RNA surveillance by human OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 4IG8 · Structural basis for cytosolic double-stranded RNA surveillance by human OAS1 · an experimental structure of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00973
- Elsewhere: UniProt P00973 · AlphaFold DB P00973
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